The effects of partial ກາວິທັດ (example on ມີນາ) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a ມີນາ partial ກາວິທັດ model. This can be beneficial to sustain long-term ມີນາ ພາລະກິດ.
ອົງການບໍລິຫານການບິນແລະອະວະກາດແຫ່ງຊາດ (ອົງການ NASA) of USA is planning to send astronauts to Moon and ມີນາ. Microgravity ເປັນທີ່ຮູ້ຈັກມີຜົນກະທົບລະບົບກ້າມຂອງຮ່າງກາຍຂອງພວກເຮົາເປັນ ກ້າມເນື້ອ and bones start to become weak. First, weight-bearing muscles like soleus, located in the calf are affected and then slow-twitch muscle fibers are lost. Mars’s gravitational pull is only 40 percent of Earth’s thus it has a lower gravity of 0.38g. It is still not completely understood how such ກາວິທັດບາງສ່ວນ can affect our body. No partial weight-bearing model has been tested until now which can mimic Martian partial gravity. More understanding in this area is critical in order to plan long space missions to ມີນາ and safe return of astronauts to Earth.
ການສຶກສາໃຫມ່ຈັດພີມມາໃນວັນທີ 18 ກໍລະກົດໃນ ຊາຍແດນຂອງ Physiology has used recently developed partial weight-bearing animal models of simulated ມີນາ partial gravity to understand how muscle deconditioning could be addressed on long ມີນາ space missions. To simulate gravity of ມີນາ, rats were fitted with full-body harness and were suspended from their cage ceiling. Divided into two groups, rats were exposed to normal loading (of Earth’s) or 40 percent loading of ມີນາ for 2 weeks. Half the number of rats in each group received either Resveratrol (RSV) – ເປັນໂພລີຟີນອລທີ່ປອດໄພທີ່ພົບໄດ້ທົ່ວໄປໃນຜິວໜັງໝາກອະງຸ່ນ, ເຫຼົ້າແວງແດງ ແລະ ບລູເບີຣີ – ໃນນໍ້າ ຫຼື ນໍ້າເທົ່ານັ້ນ. ສັດໄດ້ລ້ຽງ freely ໃນຄາບອາຫານ chow.
In ມີນາ condition, rats’ grip weakened and their calf circumference, muscle weight and slow-twitch fiber content got shrunk. Calf circumference and front and rear paw grip force were measured weekly while calf muscles were analyzed after 2 weeks . Results showed that a moderate daily dose (150 mg/kg/day) of resveratrol was seen to preserve muscle mass and strength in animals exposed to the effects of a simulated ມີນາ gravity. RSV helped restore front and rear paw grips and protected muscle mass in ມີນາ rat while having no effect on diet or body weight. RSV is known to have anti-inflammatory, anti-oxidative and anti-diabetic effects. It has been shown to promote muscle growth in diabetic animals by increasing insulin sensitivity and glucose uptake in muscle fibers. Astronauts are thought of developing reduced insulin sensitivity during space missions.
Resveratrol is seen to have a muscle-protective effect as it preserves bone and muscle mass. The current study suggests that resveratrol can help to mitigate muscle impairment in a ມີນາ partial gravity analog which mimics ມີນາ environment. It could be used as a nutritional supplement to reduce muscle and skeletal deconditioning and deterioration on long-term ມີນາ ພາລະກິດ.
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{ທ່ານສາມາດອ່ານເອກະສານການຄົ້ນຄວ້າຕົ້ນສະບັບໄດ້ໂດຍການຄລິກທີ່ລິ້ງ DOI ທີ່ໃຫ້ໄວ້ຂ້າງລຸ່ມນີ້ໃນລາຍຊື່ແຫຼ່ງທີ່ອ້າງອີງ}
ແຫຼ່ງຂໍ້ມູນ (s)
Mortreux, M. 2019. ປະລິມານຂະໜາດປານກາງຂອງ Resveratrol ປະຈໍາວັນ ຫຼຸດຜ່ອນການເສື່ອມສະພາບຂອງກ້າມຊີ້ນໃນ Martian Gravity Analog. ດ້ານໜ້າ. Physiol.
https://doi.org/10.3389/fphys.2019.00899
