ນັກວິທະຍາສາດໄດ້ລວມເອົາວັດສະດຸ nanomaterial ທີ່ມີຄຸນສົມບັດຕ້ານເຊື້ອແບັກທີເຣັຍເຂົ້າໄປໃນວັດສະດຸປະກອບປະກອບ. ອຸປະກອນການຕື່ມຂໍ້ມູນໃຫມ່ນີ້ສາມາດປ້ອງກັນການເກີດໃຫມ່ຂອງແຂ້ວຢູ່ຕາມໂກນທີ່ເກີດຈາກເຊື້ອແບັກທີເຣັຍທີ່ຮຸນແຮງ.
ແຂ້ວເລື່ອຍ (ເອີ້ນວ່າ ທັນຕະກໍາ cavities or dental caries) is a very common and widespread ແບັກທີເລຍ disease in school-going children and adults. Virulent ເຊື້ອແບັກທີເຣັຍ ຄື ເຊື້ອໂຣກ Streptococcus mutans accumulate on the surface of the tooth and start to dissolve hard tissues. Once ເຊື້ອແບັກທີເຣັຍ settle on the tooth surface, it leads to secondary (or recurrent) tooth decay at the edges of dental ຕື່ມຂໍ້ມູນ due to production of acid by cavity-causing ເຊື້ອແບັກທີເຣັຍ which now reside in the interface of dental filling and the tooth. Tooth decay caused by bacteria is responsible for failure of dental restoration material affecting 100 million patients every year. Recurrent tooth cavities and decay leads to tooth extraction and root canal treatments.
ໃນເວລາກ່ອນຫນ້າ, ການຕື່ມ amalgam ປະກອບດ້ວຍໂລຫະປະສົມໂລຫະໄດ້ຖືກໃຊ້ສໍາລັບການຟື້ນຟູແຂ້ວ. ການຕື່ມເຫຼົ່ານີ້ມີບາງ ພູມຕ້ານທານ ຜົນກະທົບແຕ່ຍັງມີຂໍ້ເສຍຂອງສີແຂງ, ເປັນພິດ mercury ແລະຂາດການຕິດຕໍ່ກັບແຂ້ວ. ໃນປັດຈຸບັນ resins ປະສົມໄດ້ຖືກນໍາໃຊ້ໃນອຸປະກອນການຟື້ນຟູແຂ້ວ, ຢ່າງໃດກໍຕາມ, ພວກເຂົາເຈົ້າຂາດຄຸນສົມບັດຕ້ານເຊື້ອແບັກທີເຣັຍທີ່ເປັນຂໍ້ເສຍປຽບທີ່ສໍາຄັນ. ນອກຈາກນີ້, ການປ່ອຍຕົວເທື່ອລະກ້າວຂອງຕົວແທນທີ່ລະລາຍຈາກຢາງໄດ້ສົ່ງຜົນກະທົບຕໍ່ຄຸນສົມບັດກົນຈັກຂອງພວກມັນເຊິ່ງເຮັດໃຫ້ຢາງ porous ຫຼືອ່ອນແອ. ວັດສະດຸປະສົມຫຼາຍຊະນິດທີ່ທົດສອບແມ່ນຈຳກັດເວລາ ແລະອາດເປັນພິດຕໍ່ເນື້ອເຍື່ອໃກ້ຄຽງ ໂດຍສະເພາະເພາະພວກມັນຕ້ອງການປະລິມານທີ່ສູງ. ການຕື່ມຂໍ້ມູນໃສ່ຢາງຢາງທີ່ສະແດງກິດຈະກໍາ inhibitory ເຊື້ອແບັກທີເຣັຍສາມາດຂັດຂວາງການພັດທະນາຂອງພະຍາດຊ່ອງປາກທີ່ແຜ່ຂະຫຍາຍເຊັ່ນ: ແຂ້ວແມງ.
ໃນການສຶກສາຈັດພີມມາໃນເດືອນພຶດສະພາ 28 ໃນ ACS ໃຊ້ວັດສະດຸແລະອິນເຕີເຟດ, researchers describe a new enhanced material having intrinsic potent ພູມຕ້ານທານ capabilities which can be used for novel dental fillings to prevent recurrent tooth decay. Same team of researchers had discovered in their earlier work that self-assembling building block Fmoc-pentafluro-L-phenylalanine-OH (Fmoc) has potent ພູມຕ້ານທານ and also anti-inflammatory properties. And, it contains both functional and structural subparts. In the current study, researchers functionally incorporated Fmoc nanoassemblies inside resin-based dental composite material using novel methods developed by them.
ໄດ້ ພູມຕ້ານທານ capabilities of this new filling material was subsequently evaluated. Researchers also analysed its mechanical strength, optical properties and biocompatibility. When resin-based composites are added with antibacterial nano-assemblies it gets the ability to inhibit and hinder growth and viability of ເຊື້ອແບັກທີເຣັຍ. The new material was non-toxic and the mechanical or optical properties of the nanaoassemblies remains unaffected by the integration. The antibacterial activity against bacterium S mutans ຕ້ອງການປະລິມານຕ່ໍາຫຼາຍຂອງວັດສະດຸໃຫມ່.
The current study demonstrates ພູມຕ້ານທານ activity of Fmoc nanoassemblies and its functional incorporation into dental resin composite filling to develop a biocompatible resin composite amalgamated material. The new filling material is pleasant looking, mechanically rigid, has high purity, is inexpensive and can be easily embedded within resin-based filling materials.
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{ທ່ານສາມາດອ່ານເອກະສານການຄົ້ນຄວ້າຕົ້ນສະບັບໄດ້ໂດຍການຄລິກທີ່ລິ້ງ DOI ທີ່ໃຫ້ໄວ້ຂ້າງລຸ່ມນີ້ໃນລາຍຊື່ແຫຼ່ງທີ່ອ້າງອີງ}
ແຫຼ່ງຂໍ້ມູນ (s)
Schnaider, L. et al. 2019. ປັບປຸງວັດສະດຸປະສົມຕ້ານເຊື້ອແບັກທີເລຍທີ່ປະກອບດ້ວຍ Nanoassembly. ACS Applied Materials & Interfaces. 11 (24). https://doi.org/10.1021/acsami.9b02839
