Scientists have developed a 3D bioprinting platform that assembles functional ມະນຸດ neural tissues. The progenitor cells in the printed tissues grow to form neural circuits and make functional connections with other neurons thus mimicking natural brain tissues. This is a significant progress in neural tissue engineering and in 3D bioprinting technology. Such bioprinted neural tissues can be used in modelling ມະນຸດ diseases (such as Alzheimer’s, Parkinson’s etc.) caused due to impairment of neural networks. Any investigation of disease of brain requires understanding how the ມະນຸດ neural networks operate.
ການພິມຊີວະພາບ 3 ມິຕິ ແມ່ນຂະບວນການເພີ່ມເຕີມທີ່ວັດສະດຸຊີວະພາບທໍາມະຊາດຫຼືສັງເຄາະທີ່ເຫມາະສົມ (bioink) ຖືກປະສົມກັບຈຸລັງທີ່ມີຊີວິດແລະພິມອອກ, ຊັ້ນໂດຍຊັ້ນ, ໃນໂຄງສ້າງສາມມິຕິຂອງເນື້ອເຍື່ອທໍາມະຊາດ. ຈຸລັງຈະເລີນເຕີບໂຕໃນ bioink ແລະໂຄງສ້າງພັດທະນາເພື່ອ mimic ເນື້ອເຍື່ອຫຼືອະໄວຍະວະທໍາມະຊາດ. ເຕັກໂນໂລຊີນີ້ໄດ້ພົບເຫັນຄໍາຮ້ອງສະຫມັກໃນ ການສືບພັນ ໃໝ່ medicine for bioprinting of cells, tissues and organs and in research as model to study ມະນຸດ ຮ່າງກາຍ ໃນ vitro, ໂດຍສະເພາະ ມະນຸດ ລະບົບປະສາດ.
ການສຶກສາຂອງ ມະນຸດ nervous system faces limitations due to unavailability of primary samples. Animal models are helpful but suffer from species-specific differences hence the imperative of ໃນ vitro models of the ມະນຸດ nervous system to investigate how the ມະນຸດ neural networks operate towards finding treatments for diseases attributed to impairment of neural networks.
ມະນຸດ neural tissues have been 3D printed in the past using stem cells however these lacked neural network formation. The printed tissue had not shown to have formed connections between cells for several reasons. These shortcomings have been overcome now.
In a recent study, researchers chose fibrin hydrogel (consisting of fibrinogen and thrombin) as the basic bioink and planned to print a layered structure in which progenitor cells could grow and form synapses within and across layers, but they changed the way layers are stacked during printing. Instead of traditional way of stacking layers vertically, they chose to print layers next to another horizontally. Apparently, this made the difference. Their 3D bioprinting platform was found to assemble functional ມະນຸດ neural tissue. An improvement over other existing platforms, the ມະນຸດ neural tissue printed by this platform formed neural networks and functional connections with other neurons and glial cells within and between layers. This is the first such case and is a significant step forward in neural tissue engineering. Laboratory synthesis of nerve tissue that mimics brain in function sounds exciting. This progress will certainly help researchers in modelling ມະນຸດ diseases of brain caused due to impaired neural network to better understand the mechanism for finding a possible treatment.
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ເອກະສານ:
- Cadena M., et al 2020. ການພິມຊີວະພາບ 3 ມິຕິຂອງເນື້ອເຍື່ອປະສາດ. Advanced Healthcare Materials Volume 10, Issue 15 2001600. DOI: https://doi.org/10.1002/adhm.202001600
- Yan Y., et al 2024. 3D bioprinting of ມະນຸດ neural tissues with functional connectivity. Cell Stem Cell Technology| Volume 31, Issue 2, P260-274.E7, February 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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