ການສຶກສາໄດ້ສະແດງໃຫ້ເຫັນວ່າເຊື້ອແບັກທີເຣັຍທີ່ພົບທົ່ວໄປໃນຜິວຫນັງຂອງພວກເຮົາເຮັດຫນ້າທີ່ເປັນ "ຊັ້ນ" ທີ່ມີທ່າແຮງຂອງການປ້ອງກັນມະເຮັງ
ການປະກົດຕົວຂອງ ມະເລັງຜິວ ໜັງ has been steadily increasing over the past decades. Skin ມະເຮັງ is of two kinds – melanoma and non-melanoma. The most common type is the melanoma skin cancer which causes 2 and 3 million cases globally every year. The non-melanoma is not the most common type and affects 130,000 globally but is also serious because it can spread. One in every three ມະເລັງ ການວິນິດໄສໃນທົ່ວໂລກແມ່ນເປັນມະເຮັງຜິວຫນັງ. ຜິວໜັງເຮົາເປັນອະໄວຍະວະທີ່ໃຫຍ່ທີ່ສຸດຂອງຮ່າງກາຍ ແລະ ຍັງສຳຄັນທີ່ສຸດ ເພາະມັນປົກຄຸມທົ່ວຮ່າງກາຍ ແລະ ປົກປ້ອງພວກເຮົາຈາກປັດໃຈພາຍນອກທີ່ເປັນອັນຕະລາຍເຊັ່ນ: ແສງແດດ, ອຸນຫະພູມທີ່ຜິດປົກກະຕິ, ເຊື້ອພະຍາດ, ຂີ້ຝຸ່ນ ແລະ ອື່ນໆ ຜິວໜັງມີໜ້າທີ່ຄວບຄຸມອຸນຫະພູມຮ່າງກາຍ ແລະ ຂັບເຫື່ອອອກຈາກຮ່າງກາຍ. ຮ່າງກາຍຂອງພວກເຮົາ. ມັນເຮັດໃຫ້ມີຄວາມຈໍາເປັນ vitamin D and marvellously, the skin provides us with a sense of touch. The main cause of skin ມະເຮັງ is overexposure to harmful rays of the sun. As the ozone layer in our atmosphere is gradually depleting the protective layer is going away leading to more UV (ultra-violet) radiation of the sun to reach the earth’s surface. Melanoma ມະເຮັງ, which starts in pigment-producing skin cells, is caused by abnormal changes in the skin when ເປັນມະເລັງ cells start growing and the main factor is somehow connected with an individual’s exposure to the sun and their history of sunburn. Non-melanoma skin ມະເຮັງ starts in the cells of the ຜິວຫນັງ and grows out to destroy nearby tissue. This type of ມະເຮັງ generally does not spread to other parts of the body (metastasize) but melanoma cancer does.
ການສຶກສາຕີພິມໃນ Science Advances ອະທິບາຍບົດບາດທີ່ມີທ່າແຮງອັນໃໝ່ຂອງ ເຊື້ອແບັກທີເຣັຍ on our skin in protecting us against ມະເຮັງ. Researchers at UC San Diego School of Medicine, USA have identified a strain of the ເຊື້ອແບັກທີເຣັຍ Staphylococcus epidermidis which is very commonly found on ສຸຂະພາບ human skin. This unique strain of skin ເຊື້ອແບັກທີເຣັຍ is seen to inhibit growth (kill) of several types of ມະເລັງ by producing a chemical compound – 6-N-hydroxyaminopurine (6-HAP) in mice. It was clear that only the mice which had this ແບັກທີເລຍ strain on their skin and thus made 6-HAP did not have ຜິວຫນັງ tumours after they were exposed to ມະເຮັງ causing UV rays. The chemical molecule 6-HAP basically impairs the synthesis (creation) of DNA thereby preventing the spread of tumour cells and also suppressing the development of new skin tumours. The mice were injected with 6-HAP every 48 hours over a period of two weeks. The strain is non-toxic and does not affect normal healthy cells while reducing the already present tumours by almost 50 percent. The authors state that the ແບັກທີເລຍ strain is adding “another layer” of protection to our skin against ມະເຮັງ.
This study clearly shows that our “skin microbiome” is an important aspect of the protection which skin offers. Some skin ເຊື້ອແບັກທີເຣັຍ are already known for producing antimicrobial peptides which protect our skin from invasions by pathogenic ເຊື້ອແບັກທີເຣັຍ. Further studies are required to understand the workings of 6-HAP and whether ideally it could be used as a preventative measure against ມະເຮັງ.
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{ທ່ານສາມາດອ່ານເອກະສານການຄົ້ນຄວ້າຕົ້ນສະບັບໄດ້ໂດຍການຄລິກທີ່ລິ້ງ DOI ທີ່ໃຫ້ໄວ້ຂ້າງລຸ່ມນີ້ໃນລາຍຊື່ແຫຼ່ງທີ່ອ້າງອີງ}
ແຫຼ່ງຂໍ້ມູນ (s)
Nakatsuji T et al. 2018. A commensal strain of Staphylococcus epidermidis ປົກປ້ອງຜິວໜັງ neoplasia. Science Advances. 4(2). https://doi.org/10.1126/sciadv.aao4502
