Coronaviruses and influenza ໄວຣັສ are sensitive to acidity of aerosol. pH-mediated rapid inactivation of coronaviruses is possible by enriching the indoor air with non-hazardous levels of nitric acid. Conversely, indoor air filter may unintentionally remove volatile acids thus prolonging persistence of airborne ເຊື້ອໄວຣັສ. This new understanding can be very helpful in controlling airborne transmission especially in indoor environment such as hospital settings.
Respiratory infections caused by ໄຂ້ຫວັດໃຫຍ່ ແລະ corona viruses are significant persistent problems for human health. Influenza alone is responsible over 400,000 deaths per year worldwide. The ongoing COVID-19 pandemic attributed to coronavirus ນະວະນິຍາຍ SARS CoV-2 has caused over 6 million deaths so far plus immense human suffering and unthinkable economic damages to world economy. Therefore, minimising transmission of these ໄວຣັສ is an extremely important priority.
It is known that their dominant mode of transmission is airborne. These infections are contracted by breathing in contaminated air. The expiratory aerosol particles act as vehicles for the transmission of influenza ເຊື້ອໄວຣັສ and novel ໂຣກ coronavirus SARS-CoV-2. Hence the importance of wearing face coverings. It is hypothesized that the ເຊື້ອໄວຣັສ can remain in the air for about 3 hours with a half-life of 1.1 hours.
Needless to say, that rapid inactivation of these ໄວຣັສ would greatly contribute to limiting their transmission.
It is known that the enveloped ໄວຣັສ like influenza and corona ໄວຣັສ are inactivated in acidic conditions however level of acidity of expiratory aerosol particles and its role on inactivation of the ໄວຣັສ was unknown.
In a recent study published in the preprint medRxiv, the researchers examined this aspect for influenza and coronaviruses. They found that the aerosol particles exhaled into indoor air become mildly acidic (pH ≈ 4). This acidic condition rapidly inactivated influenza-A ເຊື້ອໄວຣັສ within minutes but the novel ໂຣກ coronavirus SARS-CoV-2 required days for inactivation. Further, if the indoor air were enriched with non-hazardous levels of nitric acid, the acidity of the aerosol dropped by up to 2 units which in turn reduced the inactivation times for both ໄວຣັສ to below 30 seconds. This pH-mediated 99%- reduction in inactivation time could be of great significance in rapid inactivation of these ໄວຣັສ in indoor settings thus helping reduce community spread considerably.
In light the above finding, use of indoor air filters should be carefully considered because any unintentional removal of volatile acids from the indoor air may reduce acidity of expiratory aerosol and prolong airborne ເຊື້ອໄວຣັສ ຄວາມຄົງທົນ.
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ເອກະສານ:
- COVID-19: What Does Confirmation of the Airborne Transmission of SARS-CoV-2 Virus Mean? Scientific European. Posted 17 April 2021. Available at http://scientificeuropean.co.uk/covid-19/covid-19-what-does-confirmation-of-the-airborne-transmission-of-sars-cov-2-virus-mean/
- Luo B., et al 2022. Acidity of expiratory aerosols controls the infectivity of airborne influenza ເຊື້ອໄວຣັສ and SARS-CoV-2. Pre-print medRxiv. Posted March 14, 2022. DOI: https://doi.org/10.1101/2022.03.14.22272134
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