NeoCoV, a ໂຣກ coronavirus strain related to MERS-CoV found in bats (NeoCoV is not a new variant of SARS-CoV-2, the human ໂຣກ coronavirus strain responsible for COVID-19 pandemic) has been reported to be the first case of a MERS-CoV variant using ACE2. NeoCoV has potential of human emergence with both high fatality and transmission rate.
NeoCoV ແມ່ນສາຍພັນທີ່ກ່ຽວຂ້ອງກັບ MERS-CoV ທີ່ໃຊ້ເຈຍ ACE 2 receptors ສໍາລັບການເຂົ້າແລະການຕິດເຊື້ອຂອງມັນເຂົ້າໄປໃນຈຸລັງເຈຍ. ຢ່າງໃດກໍຕາມ, ສາຍພັນຂອງ MERS-CoV ໃຊ້ DPP4 receptors ສໍາລັບການເຂົ້າ cellular. ມັນເປັນສິ່ງສໍາຄັນທີ່ຈະສັງເກດວ່າ NeoCoV ບໍ່ແມ່ນຕົວແປໃຫມ່ຂອງ SARS, ດິຈິຕອ, 2 ເຊິ່ງໄດ້ພາໃຫ້ເກີດພະຍາດລະບາດໃນທົ່ວໂລກນັບແຕ່ເກີດຂຶ້ນໃນເດືອນພະຈິກ 2019.
This article shows that NeoCoV and its close relative PDF-2180-CoV is able to efficiently bind to ACE 2 receptors in bat, but bind less favourably to human ACE 2 receptors. Studies using cryo-electron microscopy revealed a distinct ເຊື້ອໄວຣັສ-ACE 2 binding surface in case of binding of NeoCoV and PDF-2180-CoV to ACE 2 receptors. A molecular determinant implicates Asp 338 residue, that prevents NeoCoV from binding to human ACE 2 receptor. In addition, a T510F mutation in the receptor binding motif of NeoCoV causes it to efficiently bind human ACE 2 receptor.
Given the high fatality rate of 35% associated with MERS-CoV related ໄວຣັສ derived from Beta CoV lineage, the NeoCoV could pose a potential threat to emergence of a high transmissible strain of NeoCoV and PDF-2180-CoV (upon gaining the T510F mutation due to antigenic drift) that can cause infection and mortality in humans, far worse than the current pandemic. Antigenic drift refers to random genetic mutations ທີ່ເຮັດໃຫ້ເກີດການປ່ຽນແປງໃນ ທາດໂປຼຕີນ ໂຄງປະກອບການ, ດັ່ງນັ້ນການປ່ຽນແປງຄວາມສາມາດຂອງທາດໂປຼຕີນທີ່ຈະຜູກມັດກັບ receptor ໂດຍສະເພາະ. ນອກຈາກນັ້ນ, ການຕິດເຊື້ອທີ່ເກີດຈາກການກາຍພັນ T510F ຂອງ NeoCoV, ບໍ່ສາມາດຂ້າມຜ່ານເປັນກາງໂດຍພູມຕ້ານທານທີ່ແນໃສ່ SARS-CoV-2 ຫຼື MERS-CoV.
The entire global community hopes that the mutation in NeoCoV and PDF-2180-CoV that causes it to efficiently bind to human ACE 2 receptor, remains a laboratory study to understand the virulence of these ໄວຣັສ, and it doesn’t become a case of zoonotic transmission from bats to humans, creating another worldwide chaos.
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ທີ່ມາ:
Yan H., et al 2022. ຍາດພີ່ນ້ອງໃກ້ຊິດຂອງ MERS-CoV ໃນເຈຍໃຊ້ ACE2 ເປັນຕົວຮັບໜ້າທີ່ຂອງພວກມັນ. ພິມ bioRxiv. ຂຽນເມື່ອວັນທີ 25 ມັງກອນ 2022. DOI: https://doi.org/10.1101/2022.01.24.477490
